Get to Know Other Various Cannabinoids found in the Cannabis Varieties

Cannabidivarine (CBDV)

It is higher in plants of Cannabis Indica than in C. Sativa. Isomerize's to Δ9-THCV under acidic conditions, biosynthetic precurcers to this.  

Anti-Inflammatory

Beneficial effects on bone formation and fraction healing

Lowers hyperphagia and abdominal obesity

Tetrahydrocannabivarin (THCV)

It has the possibility to inverse agonism both the CB1 and CB2 receptor showing  as a beneficial therapy for treating depression and suicidal ideations.

Reduction of seizures

Pain relief

Increases Weight Loss

Lowers hyperphagia and abdominal obesity

Cannabigerol (CBG)

non-psychotropic

Antibacterial Agent

THC and CBD start out as CBG

Inhibit Chronic and Inflammatory pains

Effective anit-hyperalgesic and anti-inflammatory

Cannabidiol (CBD)

Discovered in 1963 by Raphael Mechoulam

Non-psychoactive does not produce the “euphoric” feelings that are accompanied within THC, but still produce an altered state of mind

Ideal for children or people who would prefer a non-psychoactive cannabis experience

Second most abundant cannabinoid found in the hemp plant.

Inhibits obsessive behavior

Low affinity for CB1 or CB2 receptors

Protective against neurodegeneration and mental disorders

Potential benefits in Alzheimer’s disease, multiple sclerosis (MS), Parkinson’s disease and amyotrophic lateral sclerosis

Decreases uptake of adenosine and antioxidants

Immunosuppressive

Anti-Inflammatory

Anti-Anxiety like effects

Lowers blood sugar

When simultaneously administered with THC its effects are more beneficial

Cannabinol (CBN)

When THC is exposed to oxygen and heat an oxidation occurs creating CBN

Can occur over time with older cannabis or cannabis that has past maturing during its growth cycle

Anti-inflammatory

Sedation

Psychoactive

Cannabichromene (CBC)

Non-Psychoactive like THC

Relieves anxiety and stress

Anti-Inflammatory

Pain Reliever

Anti-Viral

Anti-Tumor

Stimulates bone tissue growth

Converts to CBL when exposed to lights

Cannabicyclol (CBL)

Medical properties are unknown

In comparison to other cannabinoids it is concentration is very minuscule to other properties

Possibly inhibits production of hormones that control smooth muscle contractions

Δ9-trans-tetrahydrocannabinol (Δ9-THC)

Main psychoactive compound in Cannabis Sativa isolated in Mechoulam’s Laboratory in 1964

binds to the CB2 receptor.

Immunosuppressive

Anti-inflammatory

Dampening the immune system without psychoactive effects beneficial to possibly improve autoimmune diseases and outcomes for graft rejection.

Possibly induces dependency and tolerance

Pain Reduction

Anti-Nausea

Treatment of ADHD


Δ8-trans-tetrahydrocannabinol (Δ8-THC)

Less psychotropic comparatively to  Δ9-THC

Binds to the CB1/CB2 receptors

Increases appetite

Analgesic

Neuroprotector

(Δ9-THC can be modified into D8)

anti-anxiety

Acids

Cannabidiolic Acid (CBDA)

Converts to CBD within application of heat.  

More potent than CBD within

Non-psychoactive “high” like THC

Anti-Anxiety like effects

Surpreses locomotive effects

Reduces Nausea and Vomiting

Lowers hyperphagia and abdominal obesity

Increases appetite for palatable food

Cannabigerolic Acid (CBGA)

When CBGA is broken down it is coverted into THCA or CBDA

Can be manipulated to produce higher CBG within plants through cross-needing

Lowers hyperphagia and abdominal obesity

Δ9-tetrahydrocannabinolic acid-A (THCAA)

converts to THC within application of heat.

More potent than THC

Reduces Nausea



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Work Cited:


Deiana, S., Watanabe, A., Yamasaki, Y. et al. Psychopharmacology (2012) 219: 859. https://doi- org.proxy.lib.pdx.edu/10.1007/s00213-011-2415-0

Eisenstein, Toby K., and Joseph J. Meissler. “Effects of Cannabinoids on T-Cell Function and Resistance to Infection.” Journal of Neuroimmune Pharmacology, vol. 10, no. 2, 2015, pp. 204–216., doi:10.1007/s11481-015-9603-3.11 Cannabinoids that are presented in most varieties of cannabis.

Gul, Waseem, et al. “Determination of 11 Cannabinoids in Biomass and Extracts of Different Varieties of Cannabis Using High-Performance Liquid Chromatography.” Journal of AOAC International, vol. 98, no. 6, Aug. 2015, pp. 1523–1528., doi:10.5740/jaoacint. 15-095.

Interactive, Devise. “Global Leader in Cannabis Testing and Analytics.” Steep Hill Labs, www.steephill.com/science/cannabinoids.

Journal of Neuroimmune Pharmacology, 2015, Vol.10(2), pp.204-216[Peer Reviewed Journal]

Effects of Cannabinoids on T-cell Function and Resistance to Infection

Petrocellis, Luciano De, et al. “Effects of Cannabinoids and Cannabinoid‐Enriched Cannabis Extracts on TRP Channels and Endocannabinoid Metabolic Enzymes.” British Journal of Pharmacology, Blackwell Publishing Ltd, 12 July 2011, onlinelibrary.wiley.com/doi/ 10.1111/j.1476-5381.2010.01166.x/full.

Rock, Erin M., et al. “A Comparison of Cannabidiolic Acid with Other Treatments for Anticipatory Nausea Using a Rat Model of Contextually Elicited Conditioned Gaping.” Psychopharmacology, vol. 231, no. 16, May 2014, pp. 3207–3215., doi:10.1007/ s00213-014-3498-1.

Zuardi, A.W., Hallak, J.E.C. & Crippa, J.A.S. Psychopharmacology (2012) 219: 247. https://doi- org.proxy.lib.pdx.edu/10.1007/s00213-011-2495-x